Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse, or who are experiencing emergent suicidality or symptoms that might be precursors to worsening depression or suicidality, especially if these symptoms are severe, abrupt in onset, or were not part of the patient's presenting symptoms
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As with any hormone-modulating therapy, treatment decisions should be individualized and based on a careful assessment of potential risks, expected benefits, medical history, and treatment goals
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Possibly, the neuroprotective effect of Semax on ischemia-damaged nervous tissues includes the impact of Ca 2+ penetration into the cell on the regulatory processes