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Source data underlying graphs and charts presented figures can be found in Supplementary Data 1

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For example, intradiscal injection of bone morphogenetic protein-2 (BMP-2) induced degenerative changes [92] and weekly intradiscal treatment with growth and differentiation factor-5 (GDF-5) or insulin-like growth factor-1 (IGF-1) resulted in inflammatory reactions in the adjacent vertebrae and connective tissue infiltrates in the NP, causing the IVD to collapse [93]

General Anti-Inflammatory and Wellness Applications Anecdotal reports and rodent studies have also referenced BPC-157s ability to modulate inflammation markers

One has to keep in mind that leptin takes part in the pathophysiology of both asthma and obesity and that outcomes of these diseases may overlap, especially in the context of lung function [156,192,193,194]