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Consequently, a phase 2 double-blind RCT, known as the TSUBAK trial, was conducted to evaluate whether BM could mitigate fluid retention risk and enhance eGFR in patients not at risk of heart failure (301)

They may also ask patients to complete questionnaires or keep a pain diary to help identify symptom patterns

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Morrison EE, Oatey K, Gallagher B, Grahamslaw J, OBrien R, Black P, et al

Crit Rev Toxicol 40(8):728748 Park YS, KohYH TM et al (2003) Identification of the binding site of methylglyoxal on glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185