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Important caveat: the anabolic and physique claims around IGF-1 LR3 rest largely on cell-culture and animal work plus anecdote

Hepatology 59 , 17611771 (2014)

These correlations show that 2D and 3D culture models of MNA behave very similarly in terms of drug responses, which validates drug screening in 2D cultures as not only as convenient but also meaningful method for finding new therapies for MNA