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A chronic inflammatory state with T-cell recruitment, release of cytokines and chemokines, and epithelial barrier impairment might further contribute to a dysbalanced intestinal microbiome

In the GCH1-BH4-DHFR axis, BH4, synthesized by GCH1, acts as a potent lipophilic radical scavenger that selectively protects PUFA-PLs and regulates CoQ10 synthesis, while DHFR maintains BH4 recycling to enhance defense (44, 45)

Barton DJ, Kumar RG, Schuster AA, Juengst SB, Oh BM, Wagner AK

1125) Groups of 23 weanling Sprague-Dawley rats of each sex were maintained on a diet containing 4-hexene-3-one (No

The problem may not be that the diet is grain-free or legume-heavy but that ingredients are interacting to reduce availability of taurine or that other nutrients are missing or interacting in the formulation