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Measurement of LDH activity Lactate Dehydrogenase (LDH) activity was measured by a standard kit (A020-2, Nanjing Jiancheng Bioengineering, China)

F 2 -IsoPs, F 2 -isoprostanes

Most mutations (including the p.Gly376Asp) promote cytoplasmic mislocalization [20] and formation of toxic protein aggregates [21], coupled to a depletion TDP-43 in the nucleus that causes a loss of the nuclear function of the protein [22]

In the human knee joint, the selenium concentration in cartilage is approximately 80 g/kg dry weight, whereas the selenium concentrations in ligament and meniscus are 270 and 307 g/kg dry weight, respectively 60,61

600 NASH/NAFLD HCC Non-alcoholic fatty liver disease (NAFLD) is globally prevalent and can progress to NASH, significantly increasing the risk of HCC