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The Nrf2 inhibitor brusatol has anti-inflammatory and antioxidant effects, and DHM was found to be ineffective, confirming that DHM can target Nrf2 to treat RA [151] (Table 1)

In addition to evidence of efficacy, the group also considered safety

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A Systematic Review Sophie Van Heden, Zoubayda Baoubbou, Dolores SanchezRodriguez, Yoke Mun Chan, Charlotte Beaudart Journal of Cachexia, Sarcopenia and Muscle.2026;[Epub] CrossRef Exercise, Exerkines, and Sarcopenia Hye Soo Chung, Kyung Mook Choi Diabetes & Metabolism Journal.2026