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Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge

2 Department of Bio-Pharmaceutics, Shanghai Institute of Pharmaceutical Industry, 1320 West Beijing Road, Shanghai 200040, China * To whom correspondence should be addressed

[DOI] [PMC free article] [PubMed] [Google Scholar] Silbernagl S., Heuner A

Microglial ferroptosis can activate neurotoxic astrocytes through pro-inflammatory signaling, and ferroptosis-related genes such as ALOX5/15 are highly enriched in microglia, yet this study does not establish whether ferroptosis is upstream in the cascade involving mitochondrial complex IV defects, oxidative stress, and neuroinflammation