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It is encoded in the DLD gene localized to 7q31-q32 [61], its function is to catalyze the transfer of electrons from dihydrolipoamide to NAD+and bears close structural and functional approximation to the PDE3 component of pyruvate dehydrogenase and its full complex contains 6 dimers [5].Dihydrolipoamide dehydrogenase E3k The alphaketoglutarate dehydrogenase complex EC 1.2.4.2 also termed as oxoglutarate dehydrogenase complex, acts on alphaketo-glutarate/2 oxoglutarate a key intermediate in the krebs cycle converting to succinyl co A, produces NADH and CO2 in an irreversible reaction [62] KGDHC catalyzes a vital step in the Krebs cycle, which is also a step in the metabolism of the potentially excitotoxic neurotransmitter glutamate

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Although many liposomal NAD+ and NAD+ precursor products on the market claim to enhance stability and absorption by encapsulating the molecules in these protective bubbles, the reality is that liposomes often break down during standard supplement manufacturing processes, ultimately diminishing their effectiveness