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These engineering approaches reduce bacterial activity and hypoxic targeting capability

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Moreover, SYP-14288-resistant mutant X19-7 significantly enhanced SYP-14288 metabolism on M1, and M1 accumulation in X19-7 might account for the decrease of the sensitivity to SYP-14288, whereas M2 and M3 were less important in the resistance

Management of NASH should focus on the restitution of metabolic derangements and halting inflammatory, fibrogenic, and carcinogenic pathways