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In prokaryotes, glutathione maintains the proper oxidation states of protein thiols and protects cells from damage under abnormal conditions such as low pH, chlorine compounds, oxidative and osmotic stresses 8

Homologous 1-Cys proteins are widely distributed throughout all kingdoms, and they have been described in archaea, bacteria, parasites, yeast, insects, mollusks, amphibians, birds and other orders (130) (Table I)

Prior studies have reported that active metabolites of fenofibrate can regulate metabolism, fatty acid synthesis, and other cellular processes disrupted by viral infections

Studies on autophagy and various neurodegenerative diseases are summarized in Table 1

doi: 10.1038/s41598-021-93546-5 9 BeyerstedtS.EBC.RangelB