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Because its a water-soluble vitamin, any excess is naturally flushed out by your body

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Choi YJ, Seelbach MJ, Pu H et al (2010) Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression

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In other words, glutathione also protects the cell from the outside, not simply from ROS forming on the inside of the cell

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3d), as did treatment with other TS-targeted antifolates pemetrexed and methotrexate in colon (Extended Data Fig

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