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In a study of overdoses in adults, consistent bradycardia (slow heartbeat) and a depressed central nervous system were found

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The involvement of melatonin is dose-dependent, and if at physiological concentrations, it inhibited NMDA-induced current

Taken together, these results indicate that OsDHAR has potent chaperone-like properties and is capable of protecting proteins from precipitation and heat-induced loss of enzymatic activity, suggesting that OsDHAR is a potent inhibitor of stress-induced protein aggregation