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The absence of a head-to-head trial means that prescribing decisions will initially be guided by availability, formulary coverage, individual tolerability, and prescriber familiarity rather than definitive comparative efficacy data

Aging impaired phagocytosis in tissue-resident peritoneal macrophages but not in bone marrow-derived macrophages or monocytes (Linehan et al., 2014)

Circadian rhythm sleep-wake disorders: a contemporary review of neurobiology, treatment, and dysregulation in neurodegenerative disease

The primary reason practitioners and their patients should be interested in using glutathione in IBS is that research suggests it is effective for helping maintain a normal inflammatory response in the gut, thus beneficially addressing IBD symptoms.* And in cases where the underlying mechanisms of the condition do overlap, a glutathione supplement could be just as beneficial in IBS as it is in IBD.* When glutathione facilitates antioxidant processes, it minimizes free radical exposure, which can trigger an inflammatory response imbalance.* If an imbalance in inflammatory response is involved in either IBS or IBD, then a glutathione supplement can be an appropriate choice.* Indeed, as far back as 1998, scientists have recognized that intestinal glutathione synthesis is impaired in patients with IBD, and this dysregulation might play a role in the etiology and progression of the condition

It can be hard to know what supplements to take as there is a lot of mixed information out there