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Frank, B

The low inducibility of TNF production, together with the loss of CD14 expression, is consistent with previously reported features of embryonic human microglia, highlighting functional differences between the HMC3 clone and adult primary microglial populations (162)

The GOT1-mediated glutamine metabolic pathway is a critical survival mechanism when the major glutamine pathway is inhibited, and it promotes tumorigenesis and development by replenishing the tricarboxylic acid (TCA) cycle, maintaining redox homeostasis, and providing the essential precursor, aspartic acid (Asp), for nucleotide production