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Local IGF-1 may imitate GH effects on germ cells since sperm motility and morphology are recorded to be improved due to IGF-1 production

The decreased malate/pyruvate and GSH levels with LbNOX expression strongly suggest a decreased cytoplasmic (free) [NADPH]/[NADP + ], while the large increase in pyruvate also strongly suggests that the pyruvate/lactate, a proxy for the cytoplasmic (free) [NAD + ]/[NADH], increased, which likely drove the lifespan extension in the females

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Topical evidence for skin improvement is strong at the mechanism level (collagen, elastin, GAG synthesis upregulation in fibroblasts) and moderate at the human cosmetic-trial level (Leyden 2002 conference abstract