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Furthermore, research has linked NLRP3 inflammasome activation with HIV-associated neuropathological changes, suggesting that HIV infection can induce harmful neuroinflammatory responses in the CNS (57)

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Hesperidin has also shown efficacy in the case of acute neurological pathologies such as experimental hepatic encephalopathy caused by thioacetamide [241], restoring the redox balance, as demonstrated by the decrease in MDA in both the liver tissue and the brain by increasing sirtuin-1 expression and decreasing NLPR3 and IL-1beta

Biochemistry 49:81348142

In cases of oxidative stress, it scavenges oxygen free radicals and keeps mitochondrial DNA deletion mutations in check, maintaining the whole respiratory chain