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With radiation therapy, the neurologic deficits may be improved in 5075% of cases, an effect which is usually associated with an overall improvement in health [2, 6, 7]

While research is still evolving, the compound has gained attention because of its potential connection to biological aging, sleep regulation, and cellular repair pathways

found that IL-33 could activate the NF-kB signaling pathway, which in turn could downregulate caspase-3 expression, while increase the expressions of Bcl-2 and Bax, leading to reduce the sensitivity of acute myeloid leukemia to chemotherapy (127)

In sepsis-induced acute kidney injury, spermidine improves renal outcomes by acting on macrophages, where it suppresses NLRP3 inflammasome activation and IL-1 production, preserves mitochondrial respiration, and relies on eIF5A hypusination to regulate macrophage function 118

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