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Moreover, this inert glutamine metabolism was accompanied with the down-regulation of GLS, thereby reducing the hydrolysis of glutamine and the generation of its derivative glutamate

Notably, high-grade lesions were associated with reduced IL1B and IL18 transcription, suggesting a potential immune evasion mechanism employed by HPV to promote persistence [214]

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Ferroptosis, a new form of cell death, plays an important role in glioma cell and immune cell