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RRMM patients ( N = 304) who had received 1 prior therapy line (including lenalidomide and a PI) were randomized to receive daratumumab-Pd ( n = 151) or Pd alone ( n = 153)

This finding provides a mutational (contrary to the selective one) explanation for the observation that long-lived species have GC-rich mtDNA: long-lived species become GC-rich simply because of their biased process of mutagenesis

The new oral formulation of ALA has been reported to have the potential to overcome these pharmacokinetic limitations because it uses only the R-ALA enantiomer as a liquid solution, making it more soluble and stable in the gastric environment [101, 102]

Emerging research highlights the multifaceted therapeutic potential of TQ, encompassing anti-inflammatory, anti-tumor, and free radical scavenging activities