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This treatment is a viable option for patients seeking to postpone or avoid more invasive interventions like joint replacement surgery

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

Endothelial nitric oxide synthase-derived nitric oxide prevents dihydrofolate reductase degradation via promoting S-nitrosylation

Additionally, non-pharmacological interventions such as cognitive training, cognitive behavioural therapy, and art or light therapy, previously deemed exotic, are now beginning to be integrated into therapeutic guidelines

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