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The resulting recommendations were formulated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system

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S., Zhong, Y

Human lumbar vertebrae are required to withstand pressure from more than 50% of the body weight that is further influenced by our upright posture, whereas the spine of quadrupeds, of which most models are based on, does not bear such vertical pressure in the resting state

*Correspondence: Rohit Sharma, [email protected], [email protected], Abdur Rauf, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers