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Diabetes 62 (7), 2579

10.1016/B978-0-12-803014-1.00006-6 34 EkanemE.TalaulikarV

On the other hand, only few AEDs discoveries were the result of rational, target-based strategies and were biased toward agents that modulate only a single pathology in epilepsy, that is, imbalance of GABAergic inhibition and glutamatergic excitation (Loscher et al., 2020)