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Equally important from a gerontological perspective, the SURMOUNT trials demonstrated substantial weight loss of approximately 15%20% at 72 weeks with tirzepatide, accompanied by visceral fat reduction and broad improvements in cardiovascular and metabolic risk factors, including blood pressure, fasting insulin, lipid profiles, and liver enzymes (Jastre et al., 2022)

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Cardiovascular Research, 109 (3), 374384

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism