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Kolakofsky (University of Geneva, Geneva, Switzerland)

Discussion ME/CFS, GWS, and FM are three chronic conditions presenting with overlapping symptoms, which lack definitive diagnostic tests and effective pharmacological treatments

In ME/CFS elevated plasma tryptophan levels may enhance the conversion of tryptophan to 5-hydroxytryptophan in the brain, potentially leading to central fatigue, a core symptom of ME/CFS (Castell et al., 2015)

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