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The ubiquitin-proteasome pathway and resistance mechanisms developed against the proteasomal inhibitors in cancer cells

Relative contraindications requiring caution include active or suspected cancer (GHK-Cu promotes angiogenesis with concern about theoretically feeding tumors, though conflicting data shows documented anti-cancer gene expression effects requiring medical supervision), severe organ dysfunction (kidney or liver failure may slow peptide clearance), hemochromatosis or copper overload conditions, autoimmune disorders, and patients on immunosuppressants or blood thinners

In the case of 8 8 or 10 ng/mL 14 , the prevalence of GHD in patients with short stature was 29%34%, which was higher than that in our study (20.1%)

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