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The team noted a significant reduction in the excretion of N-methylhistidine, an indicator of muscle protein breakdown

20 While there are various types of Bregs, these studies show many ways that tissue-resident Bregs can enact similar mechanisms to promote tolerogenic responses by secreting effector cytokines that act on other immune cells

More than 20% of patients experienced grade 3 adverse events (AEs), including febrile neutropenia (47%, 23/49), thrombocytopenia (37%, 18/49), leukopenia (25%, 12/49), and anemia (22%, 11/49)