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Approximately one third of patients with schizophrenia are considered to be treatment resistant [5], with the majority of these (2334%) failing to respond appreciably to dopamine-blocking antipsychotic medications from their first episode of psychosis (FEP) [6, 7]

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Cells were serially diluted and were plated onto rich or minimal medium containing the desired concentration of gliotoxin, using a multi-pronged replicator