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A recent study, in a mouse transient middle artery cerebral occlusion model (tMCAO) model shows that HSP70 overexpression inactivates NF-B by stabilizing a complex of HSP70-IB-NF-B (Zheng et al., 2008)

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This risk has not yet been confirmed in animal studies, but long-term human data do not exist

This prompted significant pushback from wellness entrepreneurs and compounding pharmacies, including litigation alleging that the agency had bypassed legally required notice-and-comment procedures in making those designations