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doi: 10.1111/j.1526-4610.2004.04170

7 The first mechanism, cerebral vasodilation, or the increase in diameter of blood vessels that cover the brain, is thought to cause the intense throbbing sensations during a migraine

Chronic or acute xenobiotic activation of the immune system would trigger self-reinforcing disease processes through failed shut-off of stress-responsiveness

Patients who do not get an adequate erection with alprostadil, or who have pain after injection, may use a combination of papaverine, phentolamine, and alprostadil called tri-mix