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The incidence and severity of discontinuation signs and symptoms vary from person to person but depend significantly on a proper gradual taper

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However, unlike imatinib treatment, the basal level of tyrosine phosphorylation in 32D progenitor cells was also reduced by ponatinib, indicating its non-specific inhibitory effect (Fig

Petersen EL, Gossling A, Adam G, Aepfelbacher M, Behrendt CA, Cavus E, Cheng B, Fischer N, Gallinat J, Kuhn S, et al