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doi: 10.1091/mbc.e08-12-1249 115 AxeELWalkerSAManifavaMChandraPRoderickHLHabermannAet al

Still, they are also a result of mitochondrial dysfunction, which occurs when mitochondria lose the protection of GSH, free radicals attack the mitochondria, and cellular energy decreases.8 Autoimmune conditions like multiple sclerosis, Crohns disease, rheumatoid arthritis, diabetes, Lyme disease, heavy metal load, organotoxins, and more all have mitochondrial dysfunction, low levels of GSH, and profound fatigue

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While Lip-1 alleviated the lethality of DEM (Figure 1E), it did not prevent the fall in glutathione that was induced by aging (as assayed on Day 4) or by DEM (Figure 1F)