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Description

Vitamin B12 deficiency causes tiredness, weakness, constipation, loss of appetite, weight loss, and megaloblastic anemia

Then, we validate our simulation by reproducing the population-level affinity maturation trajectories observed in their time-course sequencing data

This may be a consequence of the significant sparing of cytosolic GSH, which lessens the demand for and imposes negative feedback on the de novo synthesis pathway 82