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however, curcumin tends to aggregate or precipitate in the bloodstream, raising safety concerns

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Once activated, the MAPK phosphorylates diverse substrates in the cytosol and nucleus (e.g., NF-B, c-Jun, ELK-1, and activator proteinAP1), changing the protein function and gene expression of several cellular processes, such as cell growth, proliferation, differentiation, the production of pro-inflammatory cytokines development, cycle, survival, and death (Zhang and Liu 2002)