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First-in-human evaluation of the human monoclonal antibody vantictumab (OMP-18R5

10.1002/jcp.24873 26 NavarroB.KirichokY.ClaphamD

2009: A melanoma was surgically removed from her calf and a groin sentinel lymph node was clear

However, it increased heart rate, cardiac output, and induced myocardial degeneration in mice and thus was terminated as a preclinical candidate (Cui et al., 2013)