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The study showed that ROS directly activates this blocking protein to stop oocyte development

Mitew et al., 2018

GSH can be regenerated from GSSG by the enzyme glutathione reductase (GSR): NADPH reduces FAD present in GSR to produce a transient FADH-anion

Therefore, ferroptosis is not merely another form of cell death, it acts as a 'central executioner', a common endpoint where diverse neural injury signals converge