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In the Arthritis Prevention In the Pre-clinical Phase of RA with Abatacept (APIPPRA) trial, at-risk individuals were defined as individuals with arthralgia, anti-CCP plus rheumatoid factor (RF) positive or high anti-CCP titers 3 x upper limit of normal plus RF negative, without synovitis at baseline (63)

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Res J Microbiol 13(1):2836 Hou Y, Yong Z, Wu W, Wu X, Xu J (2015) Antibacterial activities of rhubarb extract and the bioactive compounds against Salmonella