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It was previously recognized that concatenation of existing domains through gene fusion, also known as protein domain mosaicism, encodes new functions in more complex organisms (Patthy, 1985)

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In this regard, certain proteins such as Kelch-like ECH-associated protein 1 (KEAP1) are activated in antioxidant response through carbonylation while insulin receptor substrates 1 and 2 are inactivated when carbonylated, which decreases insulin signaling

Yu D, Zhao Y, Li T et al (2018) Effect of electrochemical modification on the structural characteristics and emulsion storage stability of soy protein isolate

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