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General overview of some of the most important glutathione functions (synthesis, redox turnover, metabolism, signalling)

reported that short-term Anakinra therapy (12 months) only improved ACR20 and ACR50 response rates compared to placebo, with no significant differences in other efficacy endpoints (Scott et al., 2016)

10.1097/00005373-198409000-00005 36 SpositoB.BroggiA.PandolfiL.CrottaS.ClementiN.FerrareseR.et al (2021)

Additionally, the median age of children with poor treatment responses (7 years, IQR 610) was significantly older than that of children with more favorable treatment responses (5 years, IQR 48, p = 0.03)