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Late assessment: rats with ligated left colic artery and vein that underwent additional colon obstruction for three days (IC + OB rats) In deeply anesthetized rats, in addition to the left colic artery and vein obstruction by two ligations performed as described above, which resulted in a 25-mm blood-deprived colon segment, an additional colon obstruction was made close to the distal ligation using a plastic ring 4 mm in diameter

Originally developed as a tanning agent (acting via MC1R receptors), it also binds to melanocortin receptors in the brain (particularly MC3R and MC4R) that influence sexual function

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doi: 10.1177/014860710202600157 259

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