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Safety of Ixchiq was demonstrated in two clinical studies made up of approximately 3,500 participants

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Glutathione oxidized in this manner forms glutathione disulphide (GSSG), which is recycled back to GSH by the enzyme glutathione reductase (Glr1p)

A diagnosis of 5-oxoprolinemia should be considered in any patient with unexplained metabolic acidosis and a history of therapeutic acetaminophen dosing, particularly those patients with coexisting conditions that may decrease the glutathione stores

Yuan Y, Sun J et al (2023) Bloodbrain barrier endothelial cells in neurodegenerative diseases: signals from the barrier. Front Neurosci 17:1047778