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In a sensitized system especially with mast cell instability or a history of Mast Cell Activation Syndrome these same pathways can shift: Increased histamine release Neurogenic inflammation Vascular reactivity Delayed hypersensitivity-type responses What was meant to heal can present as: flushing, burning, swelling, or persistent erythema

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The excellent Higuchi correlation (R=0.97) also indicates the importance of diffusion as one of the main mechanisms contributing to the release rate

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