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Collagen synthesis is a slow process and its effects accumulate

As a result, an accumulation of Lipid-OOH occurs: since GSH is the reducing co-substrate of GPX4, able to regulate the redox state of the cell-forming Lipid-OH (Figure 2A), GSH depletion can negatively regulate GPX4, triggering ferroptosis [19]

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Peptides such as growth hormone-releasing peptides (GHRPs) have gained popularity among athletes and bodybuilders for their ability to support muscle development

Conversely, downregulation of FABP4 by apelin/apelin receptor (APLNR)-mediated Forkhead box O1 (FOXO1) suppression in ECs limits excessive FA transport and tissue accumulation, contributing to atheroprotecton against vascular diseases such as atherosclerosis [86,87,88]