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This event probably had evolutionary significance.

The ENS contains 100 million neurons and regulates the motility, the exocrine and endocrine functions, and the microcirculation of the gut

[CrossRef] [PubMed] [Google Scholar] Vitamin C and human health-A review of recent data relevant to human requirements

In copper metabolic disorders, such as Wilson's disease, copper accumulates excessively in neural tissues, particularly in the basal ganglia and other critical brain regions, leading to neurological dysfunction (120-122)