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One report surmised that endogenous corticosteroids may control TSH secretion (Samuels, 2000) via a negative feedback mechanism

Per CDC patient resources, treatment goals should be realistic (510% weight loss produces significant health benefits)

DOI: 10.1080/15563650.2019.1606432 Aroda VR et al, "Long-term metformin use and vitamin B12 deficiency in the Diabetes Prevention Program Outcomes Study." Journal of Clinical Endocrinology and Metabolism, Feb