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The human CD38 monoclonal antibody daratumumab shows antitumor activity and hampers leukemia-microenvironment interactions in chronic lymphocytic leukemia

The toxicity of hydroxypyridones might be related to the Fe 3+ complexes that may generate free radicals (Kalinowski and Richardson, 2005

DOI: 10.3390/pharmaceutics16030404

Folate trap rescue, or folate non-trapping, or not falling into the folate trap (we are using different terms to try to convey the concept) does not always occur in the situations described, but it is very common