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doi: 10.1007/s11095-007-9514-y 225

measured the GSH levels in the stratum corneum of the subjects and found that GSH in stratum corneum in acne patients was significantly lower than that of healthy controls.[] ROSACEA The UV radiation is a very well-known triggering and aggravating factor for rosacea.[] It is a potent inducer of ROS generation in the skin.[] In patients of rosacea, there is an increased ratio of oxidized to reduced glutathione compared with healthy subjects.[] A pilot, prospective, two-center, assessor-blinded study by Dall'Oglio et al

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Under these conditions, eNOS changes the nitric oxide free radical to a superoxide anion due to reduced tetrahydrobiopterin (BH4) or L-arginine (L-Arg) levels [71]