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A Catalogue of Somatic NRF2 Gain-Of-Function Mutations in Cancer

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Contact resulted in membrane disruption caused by localized oxidative damage from the mitochondria, as shown by the elevated amounts of 4-hydroxy-2-nonenal, an oxidative stress marker, which was inhibited by NAC

What the Research Says About Safety Clinical studies on AOD9604 indicate that the peptide is generally welltolerated: In human trials, no significant adverse effects were reported at doses up to 1 mg/day (safety summary) Unlike growth hormone therapies, AOD9604 does not meaningfully elevate IGF1 levels (human data), which may reduce the risk of unwanted growthrelated side effects