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Additionally, exposure to toxins, heavy metals, and oxidative stress can disrupt enzymatic activity within the cycle, affecting its overall function and metabolic stability

Crit Rev Food Sci Nutr 63(19):39803993

[DOI] [PubMed] [Google Scholar] 151.Cao Y

Clinical non-motor symptoms mainly include cognitive impairment, constipation, and sleep disorders

The catalyst is removed by filtration, and the solvent is distilled under reduced pressure to afford a solid residue, which is purified by recrystallization from aqueous ethanol to yield L-aspartyl-L-phenylalanine methyl ester