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Naruse, T

Why peptides are trending in pain and regenerative medicine What patients are asking and what physicians need to know Origins of Body Protection Compound-157 Mechanisms: angiogenesis, inflammation modulation, tissue repair Summary of preclinical data and animal pain models Early inflammatory and non-inflammatory pain studies Intra-articular BPC-157 for knee pain: what the case series showed Why current human data are hypothesis-generating, not definitive FDA status and investigational use Quality, purity, and dosing variability Theoretical biologic risks and drug interactions How peptides are marketed in regenerative clinics Cash-based models and patient demand Ethical marketing, informed consent, and medicolegal exposure Where peptides fit and dont fit in current pain practice Why evidence still matters in regenerative medicine BPC-157 shows promising preclinical data , but human evidence remains limited Current studies lack randomization, controls, and long-term outcomes Peptides are not FDA-approved for pain or musculoskeletal indications Marketing peptides without transparency poses ethical and legal risk Physicians must clearly distinguish experimental therapies from standard of care Jzwiak et al

doi: 10.1105/tpc.113.113985

Afr J Bacteriol Res

Ther 223 (2021) 107805